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docm
cluster
02/07/08=20 01:30 AM

=20 Chronic pain harms the brain [link to this post] =

http://www.sciencedaily.com/releases/2008/02/080205171755= .htm=20

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Chronic Pain Harms The Brain

ScienceDaily = (Feb.=20 6, 2008) =97 People with unrelenting pain don't only = suffer from the=20 non-stop sensation of throbbing pain. They also have = trouble=20 sleeping, are often depressed, anxious and even have = difficulty=20 making simple decisions.

In a new study,=20 investigators at Northwestern University's Feinberg School = of=20 Medicine have identified a clue that may explain how = suffering=20 long-term pain could trigger these other pain-related = symptoms.=20

Researchers found that in a healthy brain all the = regions=20 exist in a state of equilibrium. When one region is = active, the=20 others quiet down. But in people with chronic pain, a = front region=20 of the cortex mostly associated with emotion "never shuts = up,"=20 said Dante Chialvo, lead author and associate research = professor=20 of physiology at the Feinberg School. "The areas that are = affected=20 fail to deactivate when they should."

They are = stuck on=20 full throttle, wearing out neurons and altering their = connections=20 to each other.

This is the first demonstration of = brain=20 disturbances in chronic pain patients not directly related = to the=20 sensation of pain.

Chialvo and colleagues used = functional=20 magnetic resonance imaging (fMRI) to scan the brains of = people=20 with chronic low back pain and a group of pain-free = volunteers=20 while both groups were tracking a moving bar on a computer = screen.=20 The study showed the pain sufferers performed the task = well but=20 "at the expense of using their brain differently than the=20 pain-free group," Chialvo said.

When certain parts = of the=20 cortex were activated in the pain-free group, some others = were=20 deactivated, maintaining a cooperative equilibrium between = the=20 regions. This equilibrium also is known as the resting = state=20 network of the brain. In the chronic pain group, however, = one of=20 the nodes of this network did not quiet down as it did in = the=20 pain-free subjects.

This constant firing of = neurons in=20 these regions of the brain could cause permanent damage, = Chialvo=20 said. "We know when neurons fire too much they may change = their=20 connections with other neurons and or even die because = they can't=20 sustain high activity for so long," he explained. =

'If you=20 are a chronic pain patient, you have pain 24 hours a day, = seven=20 days a week, every minute of your life," Chialvo said. = "That=20 permanent perception of pain in your brain makes these = areas in=20 your brain continuously active. This continuous = dysfunction in the=20 equilibrium of the brain can change the wiring forever and = could=20 hurt the brain."

Chialvo hypothesized the = subsequent=20 changes in wiring "may make it harder for you to make a = decision=20 or be in a good mood to get up in the morning. It could be = that=20 pain produces depression and the other reported = abnormalities=20 because it disturbs the balance of the brain as a whole."=20

He said his findings show it is essential to study = new=20 approaches to treat patients not just to control their = pain but=20 also to evaluate and prevent the dysfunction that may be = generated=20 in the brain by the chronic pain.

The study will = be=20 published Feb. 6 in The Journal of Neuroscience. Chialvo's = collaborators in this project are Marwan Baliki, a = graduate=20 student; Paul Geha, a post-doctoral fellow, and Vania = Apkarian,=20 professor of physiology and of anesthesiology, all at the = Feinberg=20 School.

Adapted from materials provided by = Northwestern=20 University.

DocM

"Si vis pacem, para = bellum": If=20 you wish for peace, prepare for war.
- Flavius Vegetius = Renatus=20

"People should not fear their government; = governments should=20 fear their people."
- V, paraphrasing Thomas Jefferson=20
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1Lur= ker
star
02/11/08 12:54=20 AM

Re: Chronic pain harms the brain = 3Dnew=20 [re: docm][link to this post] =

I can believe it very easily. My wife is in = pain 24=20 hours a day 7 days a week and her mental ability has gone = done a lot=20 in the past couple of years.=20
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vogo= n13
local=20 group
02/11/08 08:43 AM

Re: Chronic pain harms the brain = 3Dnew=20 [re: 1Lurker][link to this post] =

Can we sift out changes due to just the = pain, and=20 changes due to the medication ?? =

There is plenty of room for all of God's = creatures . .=20 .

. . . next to the mashed potatoes.

Post Extras:

Oscar= 1
star
02/11/08 09:11=20 AM

Re: Chronic pain harms the brain = 3Dnew=20 [re: docm][link to this post] =

Could be, but I reckon that it must have = something to=20 do with the level of pain then. I was born with a club foot, = which=20 after seven operations was successfully set right, be it = that after=20 the second last operation I suffer a pain in the back part = of the=20 foot 24/7, already for the last 46 years. The moment I think = of it,=20 like now, for I am discussing it, I feel the pain. Usually = however,=20 unless I walk more than about 7 k's, the pain is as much = part of my=20 life as are for instance my ears, and do I not consciously=20 experience it. In addition, I sleep perfectly.=20
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