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Email Print   Text=20 = Size
Chronic=20 Pain Harms Brain's Wiring

FRIDAY, Feb. 8 (HealthDay News) -- = Chronic=20 pain can disrupt brain function and = cause=20 problems such as disturbed sleep, = depression,=20 anxiety and difficulty making simple = decisions,=20 a U.S. study finds.

Researchers at Northwestern = University's=20 Feinberg School of Medicine in Chicago = used=20 functional MRI to scan brain activity in = people=20 with chronic low back pain while they = tracked a=20 moving bar on a computer screen. They = did the=20 same thing with a control group of = people with=20 no pain.

In those with no pain, the brain = regions=20 displayed a state of equilibrium. When = one=20 region was active, the other regions = calmed=20 down. But in people with chronic pain, = the front=20 region of the cortex mostly associated = with=20 emotion "never shuts up," study author = Dante=20 Chialvo, an associate research professor = of=20 physiology, said in a prepared = statement.

This region remains highly active, = which=20 wears out neurons and alters their = connections=20 to each other. This constant firing of = neurons=20 could cause permanent damage.

"We know when neurons fire too much = they may=20 change their connections with other = neurons or=20 even die, because they can't sustain = high=20 activity for so long," Chialvo said.

"If you are a chronic pain patient, = you have=20 pain 24 hours a day, seven days a week, = every=20 minute of your life. That permanent = perception=20 of pain in your brain makes these areas = in your=20 brain continuously active. This = continuous=20 dysfunction in the equilibrium of the = brain can=20 change the wiring forever and could hurt = the=20 brain," Chialvo explained.

These changes "may make it harder for = you to=20 make a decision or be in a good mood to = get up=20 in the morning. It could be that pain = produces=20 depression and the other reported = abnormalities,=20 because it disturbs the balance of the = brain as=20 a whole," he said.

The study was published in the Feb. 6 = issue=20 of The Journal of = Neuroscience.

Chialvo said the findings show that, = along=20 with finding new ways to treat pain, = it's also=20 important to develop methods to evaluate = and=20 prevent disruption of brain function = caused by=20 chronic pain.

More information

The American Academy of Family = Physicians has=20 more about chronic pain.

3D""=20

-- Robert Preidt

SOURCE: Northwestern University, news = release, Feb. 5, 2008

Copyright =C2=A9 2008 ScoutNews, LLC. All = rights=20 reserved.

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validateSearchTerm(theForm,minChars){var = plural=3D'';if(minChars>1){plural=3D's';}if(theForm.qu.value.length0){for(var = i=3D0;i11){ap=3D'PM';}if(hour>12){hour=3Dhour-12;}if(hour=3D=3D= 0){hour=3D12;}if(hour<10){hour=3D'0'+hour;}if(minute<10){minute=3D'0'+min= ute;}var timezone=3D'';try{var tzMatch=3DdateObj.toString().match(new = RegExp('(\\w+(D|S)T)\\s+'+year));if(tzMatch&&tzMatch.length>1){timezone=3D= tzMatch[1];}}catch(e){}return MONTHS[dateObj.getMonth()]+' = '+dateObj.getDate()+', '+year+' '+hour+':'+minute+' '+ap+' = '+timezone;}function wnDateInDaylightSavings(dateObj){var = year=3DdateObj.getFullYear();var isNewDLSDates=3Dyear>2006;var = START_MONTH=3D(isNewDLSDates)?2:3;var = END_MONTH=3D(isNewDLSDates)?10:9;var = month=3DdateObj.getMonth();if(monthEND_MONTH){return = false;}var = START_DAY=3D1,SUNDAY=3D0,HOUR=3D2,DOW=3D7,DAY_MILLIS=3D86400000,EDT_OFFSE= T=3D-300,MINUTE_MILLIS=3D60000;var = tzOffset=3D(-dateObj.getTimezoneOffset()-EDT_OFFSET)*MINUTE_MILLIS;var = startDLS=3Dnew Date(year,START_MONTH,START_DAY,HOUR);var = startDay=3DstartDLS.getDay();if(startDay!=3DSUNDAY){startDLS=3Dnew = Date(startDLS.getTime()+((DOW-startDay)*DAY_MILLIS));}if(isNewDLSDates){s= tartDLS=3Dnew Date(startDLS.getTime()+(DOW*DAY_MILLIS));}startDLS=3Dnew = Date(startDLS.getTime()+tzOffset);var END_DAY=3D(isNewDLSDates)?1:31;var = endDLS=3Dnew Date(year,END_MONTH,END_DAY,HOUR);var = endDay=3DendDLS.getDay();if(endDay!=3DSUNDAY){var = offset=3D(isNewDLSDates)?DOW-endDay:-endDay;endDLS=3Dnew = Date(endDLS.getTime()+(offset*DAY_MILLIS));}endDLS=3Dnew = Date(endDLS.getTime()+tzOffset);return = dateObj>=3DstartDLS&&dateObjtxtmxlen= ){qf_errmsg=3D"Text entered in this field is "+txtlen+" chars long. The = maximum amount allowed is "+txtmxlen+".";alert(qf_errmsg);var = textarea_alert=3Ddocument.getElementById(qform.name+qelem);if(textarea_al= ert!=3Dnull){textarea_alert.color=3D"#CC0000";}return = false;}}if(dest=3D=3D'0'){var = undscrint=3Dqelem.indexOf('_');if(undscrint=3D=3D0){qform.elements[q].nam= e=3Dqelem.substr(1);}}if(qform.submittedfields!=3Dnull&&qform.elements[q]= .type!=3D"hidden"&&qform.elements[q].type!=3D"submit"){var = prev_flds=3Dqform.submittedfields.value.split("|");var = prev_flds_len=3Dprev_flds.length-2;var = prev_fld_str=3Dprev_flds[prev_flds_len];if(qform.elements[q].name!=3Dprev= _fld_str){qform.submittedfields.value+=3Dqform.elements[q].name+"|";}}}ge= nformPost(qform,qfrmcnt,customvals);return = false;}else{alert(qf_errmsg);qform.SubmitBtn.disabled=3Dfalse;document.bo= dy.style.cursor=3D'auto';return false;}}function = genformPost(qform,qfrmcnt,customvals){gen_frm=3Ddocument.gen_form_post;fo= r(i=3D0;i";}else = if(qform.elements[i].type!=3D"checkbox"&&qform.elements[i].type!=3D"radio= "){new_frm_fld=3D"";}gen_frm.innerHTML+=3Dne= w_frm_fld;}gen_frm.method=3D"POST";gen_frm.action=3Dcustomvals;gen_frm.su= bmit();}var qf_errmsg;var err_flds=3Dnew Array();function = quickFormValidate(frm,reqflds){qf_errmsg=3D"";if(err_flds){for(p=3D0;p()[\\]\\\\.,;:\\s@\\"]+(\\.[^<>()[\\]\\\\.,;:\\s@\\"]+)*)|= (\\".+\\"))@((\\[[0-9]{1,3}\\.[0-9]{1,3}\\.[0-9]{1,3}\\.[0-9]{1,3}\\])|((= [a-zA-Z\\-0-9]+\\.)+[a-zA-Z]{2,}))$');var = email_input=3Dqform.elements["LoginEmailAddress"].value;var = is_valid_email=3Demail_input.match(EmailPattern);if(is_valid_email=3D=3Dn= ull){if(bsr=3D=3D"Microsoft Internet = Explorer"&&ver=3D=3D4){err_flds[err_flds.length]=3D"LoginEmailAddress";}e= lse{err_flds.push("LoginEmailAddress");}qf_errmsg=3D"Please enter a = valid Email Address";break;}}else = if(fld.value!=3D''&&fld.name=3D=3D'_ZipCode'){var = ZipCodePattern=3D/^\d{5}(-?\d{4})?$/;var = zip_input=3Dqform.elements["_ZipCode"].value;var = is_valid_zip=3Dzip_input.match(ZipCodePattern);if(is_valid_zip=3D=3Dnull)= {if(bsr=3D=3D"Microsoft Internet = Explorer"&&ver=3D=3D4){err_flds[err_flds.length]=3D"ZipCode";}else{err_fl= ds.push("ZipCode");}qf_errmsg=3D"Please enter a valid Zip = Code";break;}}else if(fld.value!=3D''&&fld.type=3D=3D"textarea"){var = txtlen=3Dfld.value.length;var = txtmxlen=3Dfld.getAttribute("MAXLENGTH");if(txtlen>txtmxlen){if(bsr=3D=3D= "Microsoft Internet = Explorer"&&ver=3D=3D4){err_flds[err_flds.length]=3Dfldstr;}else{err_flds.= push(fldstr);}qf_errmsg=3D"Text entered in this field is "+txtlen+" = chars long. The maximum amount allowed is = "+txtmxlen+".";break;}}}}else{reqchbxname=3Dreqflds[k][0];if(reqchbxname.= indexOf('_')=3D=3D0){reqchbxname=3Dreqflds[k][0].substr(1);}var = checkbx_valid=3Dfalse;var = chkbxslen=3Dreqflds[k].length-1;for(m=3D1;m<=3Dchkbxslen;m++){var = fldchk=3Deval('document.'+frm+'.'+reqflds[k][m]);if((fldchk.type=3D=3D"ch= eckbox"||fldchk.type=3D=3D"radio")&&(fldchk.checked)){checkbx_valid=3Dtru= e;}}if(checkbx_valid=3D=3Dfalse){if(bsr=3D=3D"Microsoft Internet = Explorer"&&ver=3D=3D4){err_flds[err_flds.length]=3Dreqchbxname;}else{err_= flds.push(reqchbxname);}qf_errmsg=3D"Please fill in all required fields. = Thank you.";}}}var = err_len=3Derr_flds.length;for(u=3D0;u0){var = is_valid=3Dfalse;}else{is_valid=3Dtrue;}return is_valid;}function = quickSignupValidate(frm){qs_err_msg=3D"Please select an = email";is_valid=3Dfalse;qsform=3Deval('document.'+frm);qsformcnt=3Dqsform= .elements.length;for(v=3D0;v 1){ try { strQuery +=3D 'LaunchPageAdTag=3D' + objForm.LaunchPageAdTag.value + = '&'; //for buffering ad strQuery +=3D objForm.qsArgs.value + '&'; //for featured videos = default drop down value and player frame image if specified } catch (e) {;} =09 for (var i=3D0; i 1024) { //remove last clip properties and exit loop var index =3D strQuery.indexOf('ClipID' + (intCount - 2)); strQuery =3D strQuery.substr(0, index); break; } } } =09 if (blnClipsSelected){=09 strQuery +=3D strDefaultPaneViewVar; selectVideoPlayer(strQuery, null, null);=20 } else { // if no checkbox is checked alert ('You must select at least one video.'); } } } else { setVideoHelpPage(); } } // Writes query string for live streaming video function playLiveVideo(strLiveURI, strHeadline, strAdTag, = strHostDomain){ var strQuery =3D "vt1=3Dl&d1=3D0&ClipId1=3D" + escape(strLiveURI) + = "&LiveURI=3D" + escape(strLiveURI) + "&h1=3D" + strHeadline + "&at1=3D" = + escape(strAdTag) + "&LiveURITitle=3D" + escape(strHeadline) + = '&LaunchPageAdTag=3D' + strAdTag; selectVideoPlayer(strQuery, '', strHostDomain); } // Launches appropriate player for video function selectVideoPlayer(query, whichPlayer, hostDomain, = strClipFormat){=09 if(strClipFormat =3D=3D "flv") { launchPopupPlayer(query, hostDomain, strClipFormat); } else { var whichPlayer =3D detectWMP();=20 switch (whichPlayer){ case '6':=09 // For WMP6.4 users query +=3D '&playerVersion=3D6'; if (hostDomain =3D=3D '' || hostDomain =3D=3D null){ var nativeURL =3D 'http://' + document.domain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&' + query; } else { var nativeURL =3D 'http://' + hostDomain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&' + query; } =09 if (!window.GeckoActiveXObject){ location.href =3D nativeURL;=20 } else {=20 // For Netscape 7.1 users. Avoid setting the media address to = the location field var playerFrame =3D document.createElement("iframe"); playerFrame.id =3D "nsPlayer"; playerFrame.width =3D "0"; playerFrame.height =3D "0"; playerFrame.style.visibility =3D ""; playerFrame.src =3D nativeURL; document.body.appendChild(playerFrame); } =09 setVideoHelpPage(); break; =09 case 'null': // For users who do not install any plugins setVideoHelpPage(); break; =09 case 'mac': //for mac users with plugin installed launch native player, no = need to display help page query +=3D '&playerVersion=3D7'; if (hostDomain =3D=3D '' || hostDomain =3D=3D null){ var nativeURL =3D 'http://' + document.domain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&os=3Dmac&' + query; } else {=09 var nativeURL =3D 'http://' + hostDomain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&os=3Dmac&' + query; } =09 location.href =3D nativeURL; break; =09 case 'mac-noPlugin': //for mac users without the wmp plugin installed display help = page setVideoHelpPage('mac-noPlugin'); break; =09 case 'gecko': query +=3D '&playerVersion=3D7'; if (hostDomain =3D=3D '' || hostDomain =3D=3D null){ var nativeURL =3D 'http://' + document.domain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&' + query; } else { var nativeURL =3D 'http://' + hostDomain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&' + query; } =09 var playerFrame =3D document.createElement("iframe"); playerFrame.id =3D "nsPlayer"; playerFrame.width =3D "0"; playerFrame.height =3D "0"; playerFrame.style.visibility =3D ""; playerFrame.src =3D nativeURL; document.body.appendChild(playerFrame); setVideoHelpPage(); break; =09 =09 case '.NetServer': // for .netServer 2003 launch in native mode without any help = page query +=3D '&playerVersion=3D7'; if (hostDomain =3D=3D '' || hostDomain =3D=3D null){ var nativeURL =3D 'http://' + document.domain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&' + query; } else {=09 var nativeURL =3D 'http://' + hostDomain + = '/global/video/WorldNowASX.asp?playerType=3Dnative&' + query; } =09 location =3D nativeURL;=20 break; =09 default: // For WMP7 and above users query +=3D '&playerVersion=3D' + whichPlayer + '&hostPageUrl=3D' = + escape(document.location);=20 //pop player launchPopupPlayer(query, hostDomain); ; break;=09 }=09 } } function launchPopupPlayer(query, hostDomain, strClipFormat){ var playerurl; var winWidth; var winHeight; if(strClipFormat =3D=3D "flv") { playerurl =3D WNVIDEO_FLV_POPPLAYERURL; winWidth =3D 790; winHeight =3D 605; } else { playerurl =3D WNVIDEO_WMV_POPPLAYERURL; winWidth =3D 788; winHeight =3D 568; } =09 var strHostDomain =3D ""; =09 if (hostDomain =3D=3D '' || hostDomain =3D=3D null) strHostDomain =3D "http://" + document.domain; else=20 strHostDomain =3D "http://" + hostDomain; =09 //Reset the parent window name prior to launch popup player var windowName =3D self.name;=20 if (windowName =3D=3D "" || windowName !=3D "CONTENT") { windowName =3D "CONTENT"; self.window.name =3D windowName; } =09 var rnum =3D new Number(Math.floor(99999999 * Math.random()) + 1); var winTop =3D (screen.availHeight - winHeight)/2; var winLeft =3D (screen.availWidth - winWidth)/2; =09 var winProps =3D 'width=3D' + winWidth + ',height=3D' + winHeight +=20 = 'menubar=3Dno,location=3Dno,resizable=3Dno,scrollbars=3Dno,status=3Dno,to= olbar=3Dno,top=3D' + winTop + ',left=3D' + winLeft; var strUrl =3D strHostDomain + playerurl + query + "&rnd=3D" + rnum;=20 var objWinPopup =3D null; objWinPopup =3D window.open(strUrl, 'WNVideoPlayer', winProps); =09 try { if (objWinPopup!=3Dnull){ objWinPopup.focus(); } } catch (e) { self.blur(); } =09 return objWinPopup; } //Detect ActiveX Architecture on Both IE and on Gecko //Defer to plugin architecture for other browsers function detectWMP(){ var player; var wmp64 =3D "MediaPlayer.MediaPlayer.1"; var wmp7 =3D "WMPlayer.OCX.7"; var detectionResult =3D "null"; =09 try {=09 // browser test : check for IE(PC) 5.0 and above and NS7.1 if ((window.ActiveXObject && navigator.userAgent.indexOf('Windows') = !=3D -1)){ player =3D createActiveXObject(wmp7); if (player){ var version =3D player.versionInfo; detectionResult =3D version.substr(0,1);=20 } else {=09 player =3D createActiveXObject(wmp64); if (player){=09 detectionResult =3D '6'; }=20 } } else if (navigator.userAgent.indexOf('Mac') !=3D -1){=09 //alert(navigator.plugins['Windows Media Plugin']); //if the WMP plugin is installed if (navigator.plugins['Windows Media Plugin']) { detectionResult =3D 'mac';=09 } else { detectionResult =3D 'mac-noPlugin'; } } else if (navigator.mimeTypes['application/x-mplayer2']){ //ns or firefox detectionResult =3D 'gecko'; } } catch (error){ detectionResult =3D '6'; }=09 return detectionResult; }=09 function createActiveXObject(cid){ var error; var control =3D null; =20 if (window.ActiveXObject){ control =3D new ActiveXObject(cid); }else if (window.GeckoActiveXObject){ control =3D new GeckoActiveXObject(cid); } =20 return control; } function setVideoHelpPage(p_OS){ if (p_OS =3D=3D 'mac-noPlugin') { displayVideoHelp('mac-noPlugin'); } else if (wnvideo_getCookie('ShowWNVideoHelpPage') =3D=3D null){ displayVideoHelp(); } } function wnvideo_getCookie (name){ if (document.cookie.length>0){ var arg =3D name + "=3D"; var alen =3D arg.length; var clen =3D document.cookie.length; var i =3D 0; while (i < clen){ var j =3D i + alen; if (document.cookie.substring(i, j) =3D=3D arg) return = wmvideo_getCookieVal (j); i =3D document.cookie.indexOf(" ", i) + 1; if (i =3D=3D 0) break;=20 } return null; } } // wmvideo_getCookieVal: function to return the decoded value of a = cookie function wmvideo_getCookieVal (offset){ var endstr =3D document.cookie.indexOf (";", offset); =09 if (endstr =3D=3D -1) endstr =3D document.cookie.length; return unescape(document.cookie.substring(offset, endstr)); } ------=_NextPart_000_005C_01C86B46.4B6EE260 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://content.worldnow.com/global/tools/rsi/dm_client.js?ver=200712150300 // =0A= ------=_NextPart_000_005C_01C86B46.4B6EE260 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://js.revsci.net/gateway/gw.js?csid=E05511 /*=0A= * Build version UW-11.1.0-94=0A= */=0A= var rsi_k;=0A= var rsi_now =3D new Date();=0A= var rsi_csid =3D 'E05511';=0A= rsi_k =3D '&kd=3D' + rsi_now.getFullYear() + '_' + = (rsi_now.getMonth()+1) + '_' + rsi_now.getDate();=0A= document.writeln('
 MEMBER CENTER: "+acctmsg+" | "+loginmsg+"
MEMBER = CENTER:
  • "+acctmsg+"
  • "+loginmsg+"
    •  Welcome, "+profile+"! "+acctmsg+" | "+loginmsg+"
    Welcome, = "+profile+"!
  • "+acctmsg+"
  • "+loginmsg+"