From: Subject: In brief : Article : Nature Reviews Neuroscience Date: Wed, 20 Feb 2008 09:58:09 -0600 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C873A7.19077170" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C873A7.19077170 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nature.com/nrn/journal/v9/n3/full/nrn2352.html In brief : Article : = Nature Reviews Neuroscience

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Journal = home > Current = Issue > Rese= arch=20 Highlight > In = brief > Full = Text

Research Highlight

Nature Reviews = Neuroscience 9, 165 = (March 2008) | = doi:10.1038/nrn2352

In brief: =

Neurological disorders

Reduced social interaction and ultrasonic = communication in a=20 mouse model of monogenic heritable autism

Jamain , S. et al. Proc. Natl Acad. Sci. USA 105, 1710=961715 (2008)

  • Article

Mutations in the gene encoding neuroligin 4 (NLGN4) have been associated with autism spectrum = conditions=20 (ASCs). Here, researchers showed that mice with a mutation in Nlgn4 have altered social behaviour and memory and = reduced=20 vocalizations =97 deficits that mimic some aspects of the human = conditions. This=20 mouse might be a useful model with which to enhance our understanding of = the=20 contribution of synapse dysfunction to ASCs.

Pain

Beyond feeling: chronic pain hurts the brain, = disrupting the=20 default-mode network dynamics

Baliki , M. N. et al. J. Neurosci. 28,=20 1398=961403 (2008)

  • Article

The default-mode network consists of brain regions that = are more=20 active at rest than during task performance. In this study, patients = suffering=20 from chronic back pain showed reduced de-activation in several areas of = the=20 default-mode network during a visual-attention task, although the = patients' task=20 performance did not differ from that of control participants. The = altered=20 activity during non-pain-related information processing suggests that = disruption=20 of this network might underlie the behavioural and cognitive impairments = that=20 are associated with chronic back pain.

Sleep

Modulation of GABAA receptor = desensitization=20 uncouples sleep onset and maintenance in Drosophila

Agosto , J. et al. Nature Neurosci. 27 Jan=20 2008 (10.1038/nn2046)

  • Article

GABAA-receptor agonists increase sleep in = insomnia=20 patients, but it is unclear how the GABAA receptor regulates = sleep.=20 Here, fruit flies with a mutant form of the receptor = (RdlA302S)=20 showed greatly reduced sleep latency. Carbamazepine (CBZ) affected both = latency=20 and sleep-episode duration in wild-type flies, but in = RdlA302S flies=20 it only reduced sleep-episode duration. Moreover, CBZ increased = wild-type=20 GABAA-receptor desensitization, but not that of = RdlA302S,=20 which had a decreased rate of desensitization. These findings indicate = that=20 onset and maintenance of sleep are uncoupled, and that sleep initiation = is=20 controlled by fast-desensitizing GABAA receptors.

Learning and memory

Synaptic protein degradation underlies = destabilization of=20 retrieved fear memory

Lee , S.-H. et al. Science 7 = February=20 2008 (10.1126/science.1150541)

  • Article

Memory reconsolidation is thought to require protein = synthesis;=20 the authors of this study showed that protein degradation by the=20 ubiquitin=96proteasome system is also involved. Infusion of the = proteasome=20 inhibitor lac=20 in the CA1 of mice immediately after retrieval of a conditioned fear = memory did=20 not affect a second retrieval 24 hours later, but did prevent the=20 retrieval-impairing effect of a protein-synthesis blocker. Moreover, = lac=20 infusion in the CA1 prevented fear extinction. These findings suggest = that=20 protein degradation might destabilize pre-existing memories, allowing = them to be=20 updated and reconsolidated by protein synthesis.

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Nature Reviews Neuroscience

ISSN: 1471-003X

EISSN: 1471-0048

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DIV.error SPAN { FONT-WEIGHT: bold } #head-er HR { DISPLAY: none } #head-er .header-nonad-wrapper { PADDING-BOTTOM: 15px; BORDER-BOTTOM: #fff 1px solid } #head-er .accessibility-login-wrap { FLOAT: left; WIDTH: 100%; BORDER-BOTTOM: #000 1px solid; = BACKGROUND-COLOR: #eaeaea } #head-er .accessibility-login { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 4px; TEXT-ALIGN: right } #head-er .accessibility-login A.nature-link { FLOAT: left; FONT: bold 160%/80% Garamond, serif; WIDTH: 4.9em; COLOR: = #b1062e; MARGIN-RIGHT: 20px; TEXT-ALIGN: left; TEXT-DECORATION: none } * HTML #head-er .accessibility-login A.nature-link:hover { BACKGROUND: none transparent scroll repeat 0% 0% } #head-er .accessibility-login A.nature-link:hover { BACKGROUND: = url(/common/includes/header/images/nature.com.underline.gif) no-repeat = left bottom } #head-er .accessibility-login IMG.nature-logo { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 1px 20px 0px 0px; WIDTH: 82px! = important; HEIGHT: 11px; BORDER-RIGHT-WIDTH: 0px } #head-er .accessibility-login .jumplinks { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px; WIDTH: 45%; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; = TEXT-ALIGN: left } #head-er .accessibility-login .jumplinks LI { DISPLAY: inline; PADDING-LEFT: 15px } #head-er .accessibility-login .jumplinks LI.first { PADDING-LEFT: 0px } #head-er .accessibility-login .jumplinks A { PADDING-LEFT: 10px; BACKGROUND: = url(/common/images/icons/b1062e/arrow_down.gif) no-repeat left center; = COLOR: #000; TEXT-DECORATION: none } #head-er .accessibility-login .jumplinks A:hover { TEXT-DECORATION: underline } #head-er DIV.logon { =09 } #head-er .logon .onlyformacie { FONT-SIZE: 3px } #head-er .logon .onlyformacie { DISPLAY: none } #head-er .logon A.login { PADDING-RIGHT: 15px; PADDING-LEFT: 0px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logon.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon A.login:hover { BACKGROUND: url(/common/includes/header/images/logon_over.gif) = no-repeat right center; TEXT-DECORATION: underline } #head-er .logon A.login:active { BACKGROUND: url(/common/includes/header/images/logon.gif) no-repeat = right center } #head-er .logon A.logoff { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; FONT-WEIGHT: bold; BACKGROUND: = url(/common/includes/header/images/logoff.gif) no-repeat right center; = PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; COLOR: #b1062e; = PADDING-TOP: 0px; LETTER-SPACING: -0.1em; TEXT-DECORATION: none } #head-er .logon P { MARGIN: 0px } #head-er .logon .user { FONT-WEIGHT: bold } #head-er .logon .inst { FONT-WEIGHT: bold } #head-er .image-user-services-wrap { FLOAT: left; WIDTH: 100%; BACKGROUND-COLOR: #d6335c } #head-er .image-user-services { BORDER-BOTTOM: transparent 1px solid } * HTML #head-er .image-user-services { BORDER-BOTTOM-WIDTH: 0px } #head-er .image-user-services IMG.journal-header { BORDER-TOP-WIDTH: 0px; BORDER-LEFT-WIDTH: 0px; FLOAT: left; = BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px; WIDTH: 344px; HEIGHT: 74px; = BORDER-RIGHT-WIDTH: 0px } #head-er .user-services { FLOAT: right } #head-er .div1.user-services { WIDTH: 12.35em! important } #head-er .div2.user-services { WIDTH: 8.7em! important } #head-er .user-services UL { BORDER-RIGHT: #fff 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: #fff 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 22px 0px 21px; = BORDER-LEFT: #fff 1px solid; PADDING-TOP: 0px; BORDER-BOTTOM: #fff 0px = solid; LIST-STYLE-TYPE: none; TEXT-ALIGN: right } #head-er .user-services UL.list1 { BORDER-RIGHT: #fff 1px solid } #head-er .user-services LI { BORDER-BOTTOM: #fff 1px solid } #head-er .user-services A { PADDING-RIGHT: 13px; DISPLAY: block; PADDING-LEFT: 0px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) #767474 no-repeat right = center; PADDING-BOTTOM: 1px; TEXT-TRANSFORM: uppercase; COLOR: #fff; = PADDING-TOP: 1px; TEXT-DECORATION: none } #head-er .user-services A:hover { BACKGROUND: url(/common/images/icons/fff/arrow_s.gif) #000 no-repeat = right center } #head-er .publications-search-wrap { BACKGROUND: #000 } * HTML #head-er .publications-search { PADDING-BOTTOM: 3px; PADDING-TOP: 3px } #head-er .publications-search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 4px; = PADDING-TOP: 4px } * HTML #head-er .publications { MARGIN: 6px 0px 0px } #head-er .publications { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 4px 0px 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #head-er .publications LI { DISPLAY: inline; MARGIN-LEFT: 10px } #head-er .publications LI.first { MARGIN-LEFT: 0px } #head-er .publications A { PADDING-RIGHT: 15px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .publications A:hover { TEXT-DECORATION: underline } #head-er .search { TEXT-ALIGN: right } #head-er .search FORM { DISPLAY: inline; MARGIN: 0px } #head-er .search FORM A { PADDING-RIGHT: 14px; BACKGROUND: = url(/common/images/icons/fff/arrow_s.gif) no-repeat right center; = TEXT-TRANSFORM: uppercase; COLOR: #fff; TEXT-DECORATION: none } #head-er .search FORM A:hover { TEXT-DECORATION: underline } #head-er #searchtext { WIDTH: 10em } #head-er .publications-search LABEL { TEXT-TRANSFORM: uppercase; COLOR: #fff } #head-er INPUT { FONT-SIZE: 100% } #head-er SELECT { FONT-SIZE: 100% } #head-er .publications-search INPUT.button { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: bold; BACKGROUND: = #eaeaea; PADDING-BOTTOM: 0px; COLOR: #000; PADDING-TOP: 0px } #head-er .accessibility-login { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } #head-er .image-user-services { PADDING-RIGHT: 1%; PADDING-LEFT: 1% } 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1px solid } #global-subject-areas H4 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5 { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FONT-SIZE: 110%; BACKGROUND: = #b1062e; PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: = 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H3.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H4.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas H5.view { PADDING-RIGHT: 17px; PADDING-LEFT: 17px; FONT-SIZE: 100%; BACKGROUND: = url(/common/images/bg.7x1.b1062e.gif) #fff repeat-y left top; = PADDING-BOTTOM: 5px; MARGIN: 0px; COLOR: #9d0006; PADDING-TOP: 5px; = BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 100%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none } #global-subject-areas UL UL { FONT-SIZE: 100% } #global-subject-areas UL LI { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = LINE-HEIGHT: 150%; PADDING-TOP: 5px; BORDER-BOTTOM: #fff 1px solid } #global-subject-areas UL LI LI { PADDING-RIGHT: 0px; PADDING-LEFT: 5px; BORDER-BOTTOM-WIDTH: 0px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px } #global-subject-areas UL LI H4 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H5 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } #global-subject-areas UL LI H6 { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = FONT-WEIGHT: normal; BORDER-LEFT-WIDTH: 0px; FONT-SIZE: 100%; = BACKGROUND: none transparent scroll repeat 0% 0%; BORDER-BOTTOM-WIDTH: = 0px; PADDING-BOTTOM: 0px; MARGIN: 0px; COLOR: #666; PADDING-TOP: 0px; = FONT-STYLE: italic; BORDER-RIGHT-WIDTH: 0px } MAP.journal-nav { DISPLAY: block; MARGIN-BOTTOM: 20px } MAP.journal-nav UL { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; 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#fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.on:visited { COLOR: #fff; BACKGROUND-COLOR: #c00 } MAP.journal-nav UL LI A.submission { PADDING-LEFT: 20px! important; BACKGROUND: = url(/common/images/online_submissions.gif) no-repeat left center } MAP.journal-nav UL LI UL.subnav { BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; LIST-STYLE-TYPE: = none; TEXT-ALIGN: left } MAP.journal-nav UL LI UL.subnav LI { BACKGROUND: url(/common/images/nav_dots2.gif) #fafafa no-repeat 11px = 5px; BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0px } MAP.journal-nav UL LI UL.subnav LI.on { BACKGROUND: url(/common/images/nav_dots1.gif) #c00 no-repeat 11px 5px; = BORDER-BOTTOM: #fafafa 1px solid } * HTML MAP.journal-nav UL LI UL.subnav A { PADDING-RIGHT: 10px! important; PADDING-LEFT: 20px! important; = PADDING-BOTTOM: 2px! important; PADDING-TOP: 2px! important } MAP.journal-nav UL LI UL.subnav A:link { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:visited { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 20px; FONT-WEIGHT: = normal; FONT-SIZE: 70%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #000; = PADDING-TOP: 2px; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A:hover { BACKGROUND: url(/common/images/nav_dots1.gif) #fab934 no-repeat 11px = 5px; COLOR: #fff; TEXT-DECORATION: none } MAP.journal-nav UL LI UL.subnav A.on { COLOR: #fff } MAP.journal-nav UL LI UL.subnav A.on:visited { COLOR: #fff } #journalnav MAP.supplementary UL A { FONT-WEIGHT: normal; FONT-SIZE: 70% } #journalnav MAP.supplementary UL A:visited { FONT-WEIGHT: normal; FONT-SIZE: 70% } H2.society-resources { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; PADDING-BOTTOM: 2px; MARGIN: 0px; COLOR: #fff; PADDING-TOP: 2px; = BACKGROUND-COLOR: #fab934 } UL.society-resources { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 20px; PADDING-TOP: 0px; LIST-STYLE-TYPE: none; TEXT-ALIGN: left } UL.society-resources LI { MARGIN: 0px; BACKGROUND-COLOR: #eaeaea } UL.society-resources A { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.society-resources A:visited { PADDING-RIGHT: 5px! important; DISPLAY: block; PADDING-LEFT: 5px! = important; FONT-SIZE: 70%; PADDING-BOTTOM: 3px! important; MARGIN: 0px; = COLOR: #000; PADDING-TOP: 3px! important; TEXT-DECORATION: none } UL.society-resources A:hover { COLOR: #fff; BACKGROUND-COLOR: #fab934; TEXT-DECORATION: none } DIV.society-logo { MARGIN-BOTTOM: 20px; TEXT-ALIGN: center } DIV.society-logo IMG { WIDTH: 100% } H2.npg-resources { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 80%; 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